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The trial enrolled patients with advanced fibrosis, the population where MASH drug development has historically struggled. The readout matters because fibrosis improvement is the endpoint regulators and investors view as the clearest sign of disease modification in MASH. Merck did not disclose detailed response rates or safety data in the initial announcement. Watch for full efficacy and tolerability data, and how the profile compares with rival MASH therapies, as Merck weighs late-stage development.

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Merck (MRK), efinopegdutide

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